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The single animal study of pineal function indicates that fluoride exposure results in altered melatonin production and altered timing of sexual maturity. Whether fluoride affects pineal function in humans remains to be demonstrated. The two studies of menarcheal age in humans show the possibility of earlier menarche in some individuals exposed to fluoride, but no definitive statement can be made. Recent information on the role of the pineal organ in humans suggests that any agent that affects pineal function could affect human health in a variety of ways, including effects on sexual maturation, calcium metabolism, parathyroid function, postmenopausal osteoporosis, cancer, and psychiatric disease. SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA’s Standards. National Academies Press, Washington DC p221-22. “In conclusion, the human pineal gland contains the highest concentration of fluoride in the body. Fluoride is associated with depressed pineal melatonin synthesis by prepubertal gerbils and an accelerated onset of sexual maturation in the female gerbil. The results strengthen the hypothesis that the pineal has a role in the timing of the onset of puberty. Whether or not fluoride interferes with pineal function in humans requires further investigation.” SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 177. Original ~www.youtube.com/user …

Prolia, denosumab, a safe new drug to treat post-menopausal osteoporosis. It is monoclonal antibody, which persisted action for 6 months after subcutaneous injection, was observed. No dosage adjustment required in renal impair patients, and no observed side effect such as osteonecrosis in bisphophate drugs like Alendronate (Fosamax). It went 8 years of phase 3 human trial with no significant adverse effects, and a incredible 16.5% increase in BMD was noted afters 8 years of treatment.

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Selective Estrogen Receptor Modulators menopauseperiods.mymenopauseonline.com SERMs are a category of drugs, either synthetically produced or derived from a botanical source (Phytoserms), that act selectively as agonists or antagonists on the estrogen receptors throughout the body. The most commonly prescribed SERMs are raloxifene and tamoxifen. Raloxifene exhibits oestrogen agonist activity on bone and lipids, and antagonist activity on breast and the endometrium.Tamoxifen is in widespread use for treatment of hormone sensitive breast cancer. Raloxifene prevents vertebral fractures in postmenopausal, osteoporotic women and reduces the risk of invasive breast cancer. While most SERMs are known to increase hot flushes, Femarelle (DT56a) decreases them. In addition to the relieving effects on menopausal symptoms, Femarelle also increases bone mass density (BMD), making it protective against osteoporotic fractures. These effects are achieved by an agonistic interaction with estrogen receptors in the brain and bone. On the other hand, an antagonist interaction with estrogen receptors in the breast and uterus, has no effect on these tissues. [edit] Antidepressants Antidepressants such as paroxetine (Paxil), Fluoxetine hydrochloride (Prozac), and Venlafaxine hydrochloride (Effexor) have been used with some success in the treatment of hot flashes, improving sleep, mood, and quality of life. Paroxetine and venlafaxine may cause nausea and insomnia. In addition, venlafaxine may …

A safe new drug to treat post-menopausal osteoporosis. It is monoclonal antibody, which persisted action for 6 months after subcutaneous injection, was observed. No dosage adjustment required in renal impair patients, and no observed side effect such as osteonecrosis in bisphophate drugs like Alendronate (Fosamax). It went 8 years of phase 3 human trial with no significant adverse effects, and a incredible 16.5% increase in BMD was noted afters 8 years of treatment.

It affects women more than men and it usually sets in with age. Osteoporosis is a chronic disease in which bones become brittle and lose mass resulting in a much greater risk of fracture. Dr. David DiPaolo answers the most common questions regarding diagnosing and treating osteoporosis in this edition of Health Connection.

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